貓狗自古就水火不容，這部動畫更是將它們卷入一場勢不兩立的戰(zhàn)斗當(dāng)中。在這里，貓是最邪惡不過的動物，它們貌似平靜溫順，卻在暗中緊鑼密鼓籌劃著統(tǒng)治地球的陰謀。狗則是人類最忠實的保護者，他們忠心耿耿，要把危害人類的貓類“趕盡殺絕”。獵犬小盧正是這么一只身負重任的狗。因為，它得知了貓們正在野心勃勃，要毀滅狗類進而威脅人類。
這只毫無戰(zhàn)斗經(jīng)驗的小狗，臨危受命擔(dān)任起狗類的統(tǒng)帥，狗軍師們幫他出謀劃策。眾狗各施所長，就連人類慣用的臥底招數(shù)也成為了這場貓狗大戰(zhàn)的超級戰(zhàn)術(shù)！看來小盧要在復(fù)雜的“戰(zhàn)況”中鼓足斗志才行。
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